Journal of Molecular and Cellular Biochemistry, 385, 159–168. Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin induced diabetic rats. Srinivasan, S., Sathish, G., Jayanthi, M., Muthukumaran, J., Muruganathan, U., & Ramachandran, V. Journal of Toxicology Mechanisms and Methods. Preventive effects of oleuropein against cardiac remodeling after myocardial infarction in Wistar rat through inhibiting angiotensin-converting enzyme activity. Mnafgui, K., Khlif, I., Hajji, R., Derbali, F., Kraiem, F., Ellefi, H., et al. Effects of early angiotensin-converting enzyme inhibition in patients with non–ST-elevation acute anterior myocardial infarction. Protective effect of hydroxytyrosol against cardiac remodeling after isoproterenol-induced myocardial infarction in rat. Mnafgui, K., Hajji, R., Derbali, F., Khlif, I., Kraiem, F., Ellefi, H., et al. American Journal of Physiology: Heart and Circulation Physiology, 294, 398–406. Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice. Journal of the American College of Cardiology, 35, 569–582. Behalf of an International Forum on Cardiac Remodeling. Cardiac remodeling-concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling. Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data. Comparison of coronary plaque rupture between stable angina and acute myocardial infarction: A three-vessel intravascular ultrasound study in 235 patients. New England Journal of Medicine, 340, 115–126. Proteomics-Clinical Applications, 2, 845–861. Mitochondria: A mirror into cellular dysfunction in heart disease. Overall, eugenol evidences high preventive effects from cardiac remodeling process. However, the administration of eugenol induced a clear improvement in cardiac biomarkers injury, reduced inflammatory mediators proteins, increased heart activities of superoxide dismutase and glutathione peroxidase with reduce in thiobarbituric acid-reactive substances content and inhibition of ventricular remodeling process through inhibition of ACE activity. Else, the angiotensin-converting enzyme (ACE) activity in plasma, kidney and heart of the isoproterenol-induced rats was significantly increased by 34, 47 and 93 %, respectively, as compared to normal group. In addition, significant increases in plasma levels of inflammatory biomarkers such as fibrinogen, α1, α2, β1, β2 and γ globulins with decrease level of albumin were observed in infarcted rats as compared to normal ones. Isoproterenol-induced myocardial infarcted rats showed notable changes in the ECG pattern, increase in heart weight index, deterioration in the hemodynamic function and rise in plasma level of troponin-T, CK-MB and LDH and ALT by 316, 74, 172 and 45 %, respectively, with histological myocardium necrosis and cells inflammatory infiltration. Male Wistar rats were randomly divided into four groups, control, iso and pretreated animals with clopidogrel (0.2 mg/kg) and eugenol (50 mg/kg) orally for 7 days and intoxicated with isoproterenol (Iso + Clop) and (Iso + EG) groups. This study aimed to evaluate the antithrombotic, anti-inflammatory and anti-cardiac remodeling properties of eugenol in isoproterenol-induced myocardial infarction in rats.
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